FDA mandates “black box” for Celebrex, pulls Bextra off market
April 7, 2005
Drug giant Pfizer’s two blockbuster Cox-2 inhibitor drugs, Celebrex and Bextra, were both cited by the Food and Drug Administration for safety problems, particularly for long term users.
Last Thursday the FDA allowed Pfizer to keep Celebrex on the market if it added the “black box” warning to the physicians’ guideline. This warning is the strongest the FDA can give to doctors, and focuses on the increased chances of cardiovascular problems and gastrointestinal bleeding. Doctors should use the lowest possible dosage of Celebrex and for the shortest time necessary, it adds.
Meanwhile, Bextra was taken off the market today. Bextra users were told to stop taking the drug, according to reports.
Pfizer agreed to mandates by a blue ribbon panel of specialists, convened in February, to review the risks associated with the popular Cox-2 class of painkillers. The pills are taken by 50 million people worldwide.
The actions by the FDA are attributed to charges the agency was too slow and allowed manufacturers to report problems voluntarily. It also comes as other experimental Cox-2 drugs emerge, such as Merck’s Arcoxia and Novartis’s Prexige, and seems to raise the requirements for their future approval.
Critics said the Cox-2 inhibitors were over-prescribed and offered no more relief than cheaper over the counter medications such as ibuprofen.
Pfizer Inc (NYSE Symbol PFE) was trading at 26.90 at close on Thursday, up 0.15%
Hewlett-Packard to cut 9,000 jobs in $1 billion restructuring plan
Wednesday, June 2, 2010
Hewlett-Packard (HP) expects to lose 9,000 jobs between now and 2013 in a US$1 billion (£686m) restructuring plan.
The 9,000 jobs losses will be in the enterprise services division, but the company expects to add about 6,000 employees to its sales and delivery teams.
HP commented in a statement, “As a result of productivity gains and automation, HP expects to eliminate roughly 9,000 positions over a multi-year period to reinvest for further growth and to increase shareholder value”
HP will invest in fully automated data centers as it makes operational changes in its Internet technology services business. HP said the restructuring will generate savings of $500–700 million (about €407–571 million) in net savings after reinvestment.
Hewlett-Packard has around 300,000 employees and is the world’s largest technology company by sales. HP is an American multinational information technology corporation headquartered in Palo Alto, California.
Gay Talese on the state of journalism, Iraq and his life
Saturday, October 27, 2007
Gay Talese wants to go to Iraq. “It so happens there is someone that’s working on such a thing right now for me,” the 75-year-old legendary journalist and author told David Shankbone. “Even if I was on Al-Jazeera with a gun to my head, I wouldn’t be pleading with those bastards! I’d say, ‘Go ahead. Make my day.'”
Few reporters will ever reach the stature of Talese. His 1966 profile of Frank Sinatra, Frank Sinatra Has a Cold, was not only cited by The Economist as the greatest profile of Sinatra ever written, but is considered the greatest of any celebrity profile ever written. In the 70th anniversary issue of Esquire in October 2003, the editors declared the piece the “Best Story Esquire Ever Published.”
Talese helped create and define a new style of literary reporting called New Journalism. Talese himself told National Public Radio he rejects this label (“The term new journalism became very fashionable on college campuses in the 1970s and some of its practitioners tended to be a little loose with the facts. And that’s where I wanted to part company.”)
He is not bothered by the Bancrofts selling The Wall Street Journal—”It’s not like we should lament the passing of some noble dynasty!”—to Rupert Murdoch, but he is bothered by how the press supported and sold the Iraq War to the American people. “The press in Washington got us into this war as much as the people that are controlling it,” said Talese. “They took information that was second-hand information, and they went along with it.” He wants to see the Washington press corp disbanded and sent around the country to get back in touch with the people it covers; that the press should not be so focused on–and in bed with–the federal government.
Augusten Burroughs once said that writers are experience junkies, and Talese fits the bill. Talese–who has been married to Nan Talese (she edited James Frey‘s Million Little Piece) for fifty years–can be found at baseball games in Cuba or the gay bars of Beijing, wanting to see humanity in all its experience.
Below is Wikinews reporter David Shankbone’s interview with Gay Talese.
Contents
- 1 On Gay Talese
- 2 On a higher power and how he’d like to die
- 3 On the media and Iraq
- 4 On the Iraq War
- 5 State of Journalism
- 6 On travel to Cuba
- 7 On Chinese gay bars
- 8 On the literary canon
- 9 Sources
Moldovan government proposes awareness-raising strategy on EU integration
Monday, December 31, 2007
This week the government of Moldova approved an awareness-raising strategy on Moldova’s integration into the European Union.
The strategy was proposed to the Government by the Ministry of Foreign Affairs and European Integration; the Ministry has argued that Moldova’s citizens must be educated about the impact of the forthcoming European integration.
The draft strategy document states that Moldova does not currently have any organised system for distributing information about the European Union to its populace, and that the Government has failed to perform any targeting of information to specific demographic groups. Taking into consideration the priority placed on EU integration by the current government of Moldova, the strategy document suggests methods to improve the situation and proposes a mechanism to enable the Moldovan public to participate actively in the European integration process. It is intended that an integrated system for providing information on EU integration will provided by the Government as a result of this draft.
The new information provisions will include such projects relating to EU – Moldovan cooperation such as information centers, a free-of-charge phone line, a website, information bulletins, improvement of information held in public libraries, etc. The strategy also proposes the instruction of journalists, press officers, and functionaries working in the local public administration on the topic of EU integration.
Public tender will be invited to select the businesses that will supply key components of these projects, as the government lacks the resources needed to fully finance the implementation of the strategy from the current budget. The strategy was planned with the support of the United Nations Development Program (UNDP) and the Eurasia Foundation.
Up And Coming Home Dcor Trends

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By Hunter Pyle
One of the newest trends might surprise people until they see just how great they look. Wall murals are back in, as far as home dcor goes. The new style of wall murals isnt like you might remember from decades ago. The new trend is much more detailed and crisp looking. Walls covered in this returning style are full of depth and detail and can make a room look like one wall is a picture window overlooking something dazzling like the Las Vegas Strip or a flower filled meadow with a realistic looking running brook. You could do your sons room with an outer space mural or your daughters room could look like a majestic sky. Your den could look stylish and smart with a mural of a library or map of the world. There are gorgeous styles with skylines and beaches, underwater aquatic scenes and color combinations that are modern and chic looking.
This isnt something just designed for a playroom or a familys basement recreation room. The wall murals out today are nice enough for your great room or master bedroom. Wallpaper styles left the design books for a while in favor of paint but many new styles and returning old favorites are emerging with a new twist.
Are wall murals difficult to install?
One of the benefits of wallpaper over paint is how easy it can be installed. Not only can you transform a room quickly without worrying about covering your furniture to protect it from paint splatters but wallpaper helps to cover flaws too. Theres virtually almost no prep work required whatsoever and another benefit of wall murals is that theres not excessive matching required when piecing together a complex pattern.
Most of todays wall murals come in kit with up to eight pieces and include special wallpaper adhesive. Once youve prepared your paste (which usually comes in dry mix form to be mixed with water just prior to use) and put it on your wall, you can either position the group of panels top to bottom or one row at a time. You have a little bit of play before the adhesive dries to match it up just right and then you smooth out the wall with a wallpaper smoother.
Voila, you have just transformed your room in a few easy steps.
Frequently Asked Questions About Wall Mural Installations:
Can I put a paper mural on my stucco or textured walls? The answer is that it wont look right if you install it as-is. You need to either sand the wall until its smooth, cover the wall to create a smooth surface or choose to put up your mural on a different wall.
Are murals easy to remove when I want to redecorate? Yes, although the paper is slightly different than typical wallpaper, wall murals are quite easily removable.
Can I wash the wall that my wall mural is installed on? Yes. Wall murals are durable. While you can not scrub your wall with harsh chemicals, you can sponge off lightly to remove fingerprints and light dirt
About the Author: This article was written to talk about a new trend in Home Decor. With this said, I would highly recommend visiting
Taylor Gifts
to find out more about Home Decor items that can improve the look and feel of your home.
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US salmonella outbreak linked to peanut butter, brand recalls product
Sunday, January 11, 2009
According to the Centers for Disease Control and Prevention, an outbreak of salmonella that has affected at least 399 people in 42 different U.S. states has been linked to King Nut, an American brand of peanut butter. In Minnesota, the state’s Health Department announced that bacteria tests for the disease on a tub of creamy King Nut peanut butter had tested positive for the disease, initiating a recall by its distributor in Solon, King Nut Companies.
Workers found evidence from these tests that the brand caused the outbreak. This has not been completely proven, however, as the Food and Drug Administration and King Nut itself are still conducting tests to discover if the case is isolated or related to the nationwide incident.
According to a statement made by the Health Department, the brand is used in many places including schools, hospitals, some restaurants and retirement homes, 20 alone being in Minnesota. A tub of peanut butter used inside of a retirement home where many of its citizens had become sick was tested positive by Minnesota’s health department.
We are very sorry this happened. We are taking immediate and voluntary action because the health and safety of those who use our products is always our highest priority. | ||
Yesterday, King Nut Companies recalled all peanut butter distributed by their company. The president of King Nut Companies, Martin Kanan, said in a statement yesterday, “We are very sorry this happened. We are taking immediate and voluntary action because the health and safety of those who use our products is always our highest priority.”
In a web statement, King Nut told all of its customers to “put on hold all of their peanut butter in question. A recall of this product will be announced Monday morning. At this point it is unclear what Peanut Corporation of America will do with regard to this case or the national case of the salmonella outbreak.” The Peanut Corporation of America, located in Lynchburg but also operating in the states of Texas and Georgia, is the manufacturer for King Nut.
Salmonellosis is an infection of salmonella bacteria that usually results in diarrhea, fever, vomiting, and abdominal cramps. These symptoms are normally developed 12 to 72 hours after a person is infected, and can last anywhere from 3 to 7 days. Most of the time, the infected person will recover from the disease, but younger and older people have higher risks of it developing and becoming serious. Rarely, salmonella can cause hospitalization, and very rarely, it can lead to death.
Author Amy Scobee recounts abuse as Scientology executive
Monday, October 11, 2010
Wikinews interviewed author Amy Scobee about her book Scientology – Abuse at the Top, and asked her about her experiences working as an executive within the organization. Scobee joined the organization at age 14, and worked at Scientology’s international management headquarters for several years before leaving in 2005. She served as a Scientology executive in multiple high-ranking positions, working out of the international headquarters of Scientology known as “Gold Base”, located in Gilman Hot Springs near Hemet, California.
Woman hospitalized after allegedly stabbing daughter to death at Fort MacArthur, California
Wednesday, July 14, 2010
On Friday, the Los Angeles Police Department arrested and charged a woman with murder, after she reportedly stabbed her ten-year-old daughter to death at the Air Force base Fort MacArthur residential facility in San Pedro, California. The girl’s father is a former member of the Navy.
The 49-year-old mother, Bong Sook Chavez, allegedly slit her daughter’s wrists and neck. Chavez slit her own wrists after attacking her daughter. In a statement issued on Monday, investigators say Chavez likely stabbed her daughter while she was asleep in bed.
Deputy Chief Pat Gannon told the Los Angeles Times Chavez has a history of mental health problems. According to Gannon, “The father was able to get the weapon away from her.” The father awoke at around 2:30 a.m. local time to find Chavez attacking her daughter.
The daughter, Quesi Chavez, later died at the University of Southern California’s Medical Center as a result of her wounds. As of Monday, the mother remained in the hospital in stable condition, but was scheduled to appear in court yesterday.
2 Important Features Of Crm Software Financing You Need To Know &Amp; 2 Most Important Guidelines To Be Kept In Mind While Opting For Manufacturing Software Financing

Submitted by: Chris Mark Fletcher
When you set up a business, there are certain guidelines that you use to start and grow in your field. The priority is always given to customer satisfaction. It is very important to get feedback from your customers so you as an entrepreneur can do better.
Customer feedback helps you grow and make those necessary changes to the business set up which may not have been noticeable through the entrepreneur s eyes but which the customer knows better. Feedback as such does help one move in right direction and with the right momentum. So if you wish to get the same for your business then you need to try the customer relationship management software which is also known as the CRM software.
The following mentioned points are of major help, as they allow you to know more about the software finance options available to you:
Easy low cost software options:
A lot of people hold the impression that spending on software as such is a waste of time. But all they need to do is let go off this misconception. It is nothing but a wrong seed being sowed. The CRM software as such is very much capable of bringing about the desired results. More so, it helps in building rapport with the customers which precisely is the main goal of the business owner. This software is not fancied by many because of the cost, but even if it is expensive, the benefits are many. The final result brings in massive amount of profit that will allow you to own your own CRM software.
Financing plans can be customized according to your needs:
When going for software financing option, it is very important that you get your hands on a top notch firm, a firm that is good enough to be trusted. The reliability can be tested only when you are sure of the option that you have picked. A little research can help you to choose the best firm. With so many options open, there is a possibility to choose the wrong one.
Therefore one should be very sure of the choice made.
If you are amongst those who are opting for financial help for the first time then it becomes even more important to take in the advice of an expert. If you can t find any such experts in and around your locality then the option of the internet is always open.
2 Most Important Guidelines to Be Kept In Mind While Opting For Manufacturing Software Financing
When it comes to most business firms, they change their manufacturing software to meet their changing requirements. The reasons for the change are however many. There might be different software that is available on the market that promises you the desired results. But one should not fall for all such deals because all the software that are available in the market are not reliable.
So the right choice has to be made. If you are doing this for the first time then it becomes even more important to make sure that you choose the right one. To make this process easy, you could always take the assistance of an expert. The expert as such ensures that you get suitable and reliable software so that the best service is provided.
The credentials of the expert should also be checked well before zeroing on one. There are many experts available online and their credentials are also mentioned. So, one should get back to them on the mentioned address or any such reliable means so that there is a sense of assurance at the end of it all. These experts help you with tips and guidelines so that you can choose the best software financing option. The following paragraphs provide some important tips that you can use while choosing any means of help like experts while taking such financial decisions.
Finding the best expert on board – The problem that most people face in the initial stage is with the experts. With so many experts out there, choosing a reliable one from so many is something that needs to be looked into. If the people that you know cannot help you out with one then the medium of internet is always an option to go with. Basically, it is the best option to go with as there are many experts to choose from.
Get information about financing company – If you plan to finance manufacturing software for your business then you should be well aware of the process related to it as well as the company financing it. The details are important as they decide the momentum and direction you are heading into.
About the Author: Chris Fletcher shares his knowledge about
Software Finance
solutions. For more details visit:
crestcapital.com/Catalog
Source:
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